Rufinamide|cas 106308-44-5|DC Chemicals

Cas No.:	106308-44-5
Chemical Name:	Rufinamide
Synonyms:	Rufinamide;1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE, 1-[(2,6-DIFLUOROPHENYL)METHYL]-;1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide;1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide;CGP 33101;E 2080;RUF 331;Inovelon;RufinaMide(Banzel);Rufinamide solution;Rufinamide (200 mg);Banzel;Xilep;1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide;WFW942PR79;C10H8F2N4O;POGQSBRIGCQNEG-UHFFFAOYSA-N;E2080;DSSTox_RID_81675;DSSTox_CID_26506;DSSTox_GSID_46506;1-[(2,6-difluorophenyl)
SMILES:	NC(=O)C1=CN(N=N1)CC2=C(F)C=CC=C2F
Formula:	C₁₀H₈F₂N₄O
M.Wt:	238.1935
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
In Vitro:	Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD).
References:	[1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.

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