Sumanirole maleate|cas: 179386-44-8|DC Chemicals

Cas No.:	179386-44-8
Chemical Name:	(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
Synonyms:	(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate;Sumanirole maleate;U 95666E(SUMANIROLE MALEATE);, Sumanirole maleate, PNU 95666, U95666E;cc-479;PNU 95666;S2191_Selleck;SureCN1229224;U 95666E, Sumanirole maleate, PNU 95666, U95666E;UNII-2OI87T3R1B;(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate;(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate;CID 9818479 maleate;PNU-95,666 maleate;U95666E;PNU 95666E
SMILES:	OC(=O)\C=C\C(O)=O.CNC1CN2C3C(=CC=CC=3C1)NC2=O
Formula:	C₁₁H₁₃N₃O^.C₄H₄O₄
M.Wt:	319.31258
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
Target:	D2 receptor
References:	[1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587

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