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ALV1

  Cat. No.:  DC67328   Featured
Chemical Structure
2438124-79-7
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More than 5000 active chemicals with high quality for research!
Field of application
ALV1 is a molecular glue degrader targeting Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. It binds to CRBN with an IC50 of 0.55 µM and induces CRBN-Helios dimerization. ALV1 is a valuable tool for studying the properties and functions of regulatory T cells (Treg cells).
Cas No.: 2438124-79-7
Chemical Name: ALV1
Synonyms: Benzenepropanamide, N-(3-chloro-4-methylphenyl)-3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]-;ALV1
SMILES: C1(CCC(NC2=CC=C(C)C(Cl)=C2)=O)=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1
Formula: C25H23ClN4O5
M.Wt: 494.93
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC60948 NEK7 degrader (Compound 17) NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
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