COH34|CAS 906439-72-3|DC Chemicals

Cas No.:	906439-72-3
Chemical Name:	(E)-1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol
Synonyms:	COH34; COH-34; COH 34
SMILES:	OC1=CC=C2C=CC=CC2=C1/C=N/SC3=CC=C(C)C=C3
Formula:	C₁₈H₁₅NOs
M.Wt:	293.38
Purity:	>98%
Sotrage:	0°C (short term), -20°C (long term), desiccated

Description:	COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
Target:	IC50: 0.37 nM (PARG)[1]
In Vivo:	COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
In Vitro:	COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].
References:	[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.

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