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dCeMM1

  Cat. No.:  DC60567   Featured
Chemical Structure
118719-16-7
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More than 5000 active chemicals with high quality for research!
Field of application
dCeMM1 is a molecular glue degrader targeting RBM39. It functions by redirecting the activity of the CRL4DCAF15 ligase, leading to a reduction in RBM39 levels in WT KBM7 cells.
Cas No.: 118719-16-7
Chemical Name: dCeMM1
Synonyms: N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide;dCeMM1;(E)-N'-(5-bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide;N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]-4-methylbenzenesulfonamide;STL432310;118719-16-7;SMR000364857;AKOS001020225;SR-01000211832-1;CHEMBL3197745;MLS000775106;SR-01000211832;CS-0190566;Z49616871;HY-W133627;(E)-N'-(5-Bromo-2-hydroxybenzylidene)-p-toluenesulfonohydrazide;MS-25924;N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-4-methylbenzenesulfonohydrazide;EX-A7627;REGID_for_CID_5511001;N'-[(1E)-(5-bromo-2-hydroxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide;MFCD00415337
SMILES: BrC1C=CC(=C(C=1)/C=N/NS(C1C=CC(C)=CC=1)(=O)=O)O
Formula: C14H13BrN2O3S
M.Wt: 369.23
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC60948 NEK7 degrader (Compound 17) NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
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