EMBL|CAS 445222-91-3|DC Chemicals

Cas No.:	445222-91-3
Chemical Name:	MuRF1-IN-1
Synonyms:	MuRF1-IN-1;Oprea1_487101;RSC004160;STK863604;ST071760;1'-Methyl-2',5-dioxo-5,6,7,8-tetrahydro-2-aminospiro[4H-1-benzopyran-4,3'-indoline]-3-carbonitrile;2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene];2-amino-1'-methyl-2',5-dioxo-1',2',5,6,7,8-hexa-hydrospiro[chromene-4,3'-indole]-3-carbonitrile;2-amino-1'-methyl-2',5-dioxo
SMILES:	O1C(=C(C#N)C2(C(N(C)C3C=CC=CC2=3)=O)C2C(CCCC1=2)=O)N
Formula:	C₁₈H₁₅N₃O₃
M.Wt:	321.330003976822
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Novel inhibitor of MuRF1, attenuating skeletal muscle atrophy and dysfunction in cardiac cachexia
References:	[1]. Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.

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