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GSK-1842799

  Cat. No.:  DC70450  
Chemical Structure
1005407-76-0
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More than 5000 active chemicals with high quality for research!
Field of application
GSK-1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM; displays an excellent selectivity (>3,000-fold) for S1P1 over S1P3; significantly reduces blood lymphocyte at 3 mg/kg, achieves efficacy equivalent to FTY720 in the mouse EAE model of MS.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1005407-76-0
Chemical Name: GSK-1842799
Synonyms: GSK1842799
Formula: C20H28F3N3O2S
M.Wt: 431.518
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
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DC10925 SAR-100842 SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
DC10924 BMS986202 BMS-986202 is a clinical Tyk2 inhibitor that binds to Tyk2 JH2 with IC50 of 0.19 nM and shows remarkably selectivity over other kinases including Jak family members.
DC8622 AM095 free acid AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
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