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(R)-SR-C-107

  Cat. No.:  DC76311  
Chemical Structure
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Field of application
(R)-SR-C-107 is an orally available inhibitor of ENL (YEAST domain-containing protein) designed to target acute myeloid leukemia (AML). (R)-SR-C-107 targets ENL with IC50 and KD of 40 nM and 144 nM, respectively. (R)-SR-C-107 demonstrates in vivo efficacy in a xenograft mouse model of AML, with a tumor regression rate of 45% at a dose of 200 mg/kg (PO; QD).
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.:
Chemical Name: (R)-SR-C-107
SMILES: O=C(C1=CN2C(C=C1)=NN=C2)NC3=CC(NC(CN4[C@@H](C(C)C)CC4)=C5)=C5C=N3
Formula: C21H23N7O
M.Wt: 389.45
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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