SBP-3264|STK3/4 inhibitor ||DC Chemicals

Cas No.:	2869148-13-8
Chemical Name:	SBP-3264
SMILES:	ClC1=CC=CC(C2=CNC3=NC=NC(N4CCC(CC4)NC(C)=O)=C32)=C1
Formula:	C₁₉H₂₀ClN₅O
M.Wt:	369.85
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Nicole Bata, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369.

Description:

SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and possessed favorable pharmacokinetic and pharmacodynamic properties in mice. SBP-3264 suppress the proliferation of AML cells in vitro. SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in AML.

References:

1. Nicole Bata, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369.

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