UCM05|CAS 1094451-90-7|DC Chemicals

Cas No.:	1094451-90-7
Chemical Name:	G 28UCM
Synonyms:	UCM05;G 28UCM;3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate;Benzoic acid, 3,4,5-trihydroxy-, 1,1'-(1,3-naphthalenediyl) ester
SMILES:	C1(C2(=CC(O)=C(O)C(O)=C2)C(O)=O)=C2C(C=CC=C2)=CC(C2(=CC(O)=C(O)C(O)=C2)C(O)=O)=C1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

References:

[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131. [2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

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UCM05(G 28UCM)