VU534|CAS 923509-20-0|DC Chemicals

Cas No.:	923509-20-0
Chemical Name:	VU534
SMILES:	O=C(C1CCN(S(=O)(C2=CC=C(F)C=C2)=O)CC1)NC3=NC4=CC(C)=CC(C)=C4S3
Formula:	C₂₁H₂₂FN₃O₃S₂
M.Wt:	447.54

Cat. No.	Product name	Field of application
DC71386	(2E)-OBAA	(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM.
DC70891	VU0285655-1	VU0285655-1 is a potent, selective inhibitor of PLD2, induces autophagy in colorectal cancer cells
DC45583	Trans-4-Phenyl-3-buten-2-one	Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
DC44081	7-Hydroxycoumarinyl arachidonate	7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonat e is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin. Release of 7-HC can be measured using a fluorometer.
DC43940	Melittin	Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
DC28606	MJ33	MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6. MJ33 has a critical effect on inflammatory brain damage.
DC28393	Halopemide	Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.
DC7966	U73122	U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).
DC9589	D609	D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent.
DC76883	Ro 23-9358	Ro 23-9358 is a potent secretory phospholipase A2 inhibitor with anti-inflammatory activity.