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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC8708 Spirodiclofen
Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.
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DC21769 Spiradoline mesylate
Spiradoline (U 62066) is a potent, highly selective κ-opioid agonist that has analgesic diuretic and antitussive effects..
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DC21768 Spiradoline
Spiradoline (U 62066) is a potent, highly selective κ-opioid agonist that has analgesic diuretic and antitussive effects..
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DC21677 SPI009
SPI009 is a novel antipersister compound active against P. aeruginosa.
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DC12592 SPL7
Sphynolactone-7 (SPL7) is a potent, specific, femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica with minimum effective concentration (MEC) of 10 fM that produces any seed germination.
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DC22231 Sphynolactone-7
Sphynolactone-7 (SPL7) is a potent, specific, femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica with minimum effective concentration (MEC) of 10 fM that produces any seed germination.
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DC7298 MY-5445
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).
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DC21676 SPA70
SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells.
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DC21675 SP 4206
SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.
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DC20634 Sovaprevir
Sovaprevir (ACH-1625, ACH-0141625) is a potent HCV NS3/4A inhibitor in development for the treatment of hepatitis C..
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DC11034 SOS1 activator 17
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro.
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DC22778 Sortin1
Sortin1 is a small molecule sorting inhibitor (Sortin) that induces reversible defects in vacuole biogenesis and root development in Arabidopsis seedlings at 100 mg/liter (227 uM).
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DC10249 Sodium sulfadiazine
Sodium Sulfadiazine is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.
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DC8920 Sodium picosulfate
Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
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DC20213 Sodium L-lactate
Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.
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DC7505 Sodium-Channel-inhibitor-1
Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
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DC9540 sodium 4-pentynoate
sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.
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DC11020 SOD1-Derlin-1 inhibitor 56-59
SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assay.
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DC23803 SNX-9114
SNX-9114 (SNX9114, PF-04944733) is a small molecule Hsp90 inhibitor with excellent brain permeability..
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DC21674 SNX-0723
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
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DC11318 SNVP
SNVP is an S-nitrosothiol that acts as a nitric oxide (NO) donor and vasodilator.
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DC21953 SNIPER(ER)-110
SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells.
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DC22792 SNIPER(AR)-51
SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.
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DC11584 SNIPER(ABL)-062
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
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DC21671 SNAP-94847
SNAP-94847 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 1.69 nM.
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DC21670 SNAP-7941
SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM.
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DC12597 SN79 dihydrochloride
SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative σ receptor antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.
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DC11796 SN-32976
SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.
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DC9622 SN 2
SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM.
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DC20555 Smoothib
Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
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