Potent long-acting H2-receptor antagonist

Novel fluorescent activity-based probe (ABP), being intrinsically dark and only emitting fluorescence after reaction with the target protease, are ideally suited for imaging techniques such as small animal noninvasive fluorescence imaging and live cell fl

G-quadruplex ligand, decreasing oncogene expression

Novel pan-genotype inhibitor of HCV NS5B polymerase via binding to the primer grip site

Novel γ-secretase modulator

Novel S1P1 receptor modulator

Novel GPR119 agonist

Selective RARγ agonist

Novel Agonist of Sphingosine-1-Phosphate (S1P1)

Potent and selective GPR119 agonist

Potent alpha7 Nicotinic receptor partial agonist, improving cognition in preclinical rodent model

Novel inhibitor of the influenza nucleoprotein (INF-NP)

Novel potent and selective P2Y1 purinergic receptor antagonist.

Potent, Orally Bioavailable, Metabolically Stable Thumb Site 1 Inhibitor of the Hepatitis C Virus NS5B RNA-Dependent, RNA Polymerase

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel Novel γ-secretase modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Novel, potent, exceptionally selective inhibitor of TNF-α Converting Enzyme (TACE)

Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Prodrug of the novel fluoro-substituted camptothecin analog, BMS-286309

Novel Selective CYP17A1 Lyase Inhibitor

Novel dissociated glucocorticoid receptor modulator

Novel fluoro-substituted camptothecin, inducing topoisomerase I-mediated DNA breaks

Highly potent and selective phosphodiesterase 5 (PDE 5) inhibitor

Potent and selective beta-lactam tryptase inhibitor, inhibiting factor XIa and producing antithrombotic efficacy with minimal bleeding time prolongation

Selective ATP hydrolase inhibitor

Potent and selective p56(lck) inhibitor