ARN14988 is a potent inhibitor of acid ceramidase that increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells.

CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.

Ibuprofen carboxylic acid is a major metabolite of ibuprofen.

Terpendole C is an indole diterpene alkaloid fungal metabolite and inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT). It also inhibits ACAT in J774 macrophages without affecting cell growth.

BODIPY 558/568 C12 is a fatty acid-conjugated fluorescent probe for lipid droplets. It displays excitation/emission maxima of 558/568 nm, respectively, and has been used to monitor the localization and dynamics of lipid droplets in live cells.

Martinomycin is a polyether antibiotic active against a variety of bacteria including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis.

Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682. TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B, but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.

Deoxyfusapyrone is an α-pyrone fungal metabolite that has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses. Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium.

Siamycin I is a tricyclic peptide with antiviral and antibacterial activities. It is active against HIV-1 and CBL-20 strain of HIV-2. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells. It is also active against B. subtilis, M. luteus, and S. aureus. Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).

Z-LRGG-AMC TFA is a fluorogenic substrate for isopeptidase T. Upon enzymatic cleavage by isopeptidase T, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify isopeptidase T activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

BODIPY 503/512 is a lipophilic, amine-reactive fluorescent probe. It has been used to label oligonucleotide probes and primers for the quantitation of DNA and RNA by PCR and to monitor the uptake and trafficking of BODIPY-labeled proteins and other compounds within cells by fluorescence microscopy. BODIPY 503/512 has also been used to identify and sort adipocytes from mouse white and brown adipose tissue by flow cytometry. It displays excitation/emission maxima of 503/512 nm, respectively.

Aminopyralid is a selective herbicide used for control of broadleaf weeds, especially thistles and clovers. It is in the picolinic acid family of herbicides, which also includes clopyralid, picloram, triclopyr, and several less common herbicides.

2-Aminofluorene is a biochemical.

AL-6598 is a DP prostaglandin receptor agonist which may lead to sustained intraocular pressure reduction. This bioactivity may be useful in the treatment of glaucoma.

GT-2016 is an H3 antagonist that may play a role in cognition.

Methimepip dihydrobromide is a histamine agonist which is highly selective for the H3 subtype. It is the N-methyl derivative of immepip.

Doxycycline monohydrate is a synthetic tetracycline derivative with similar antimicrobial activity.

(R)-Azelastine hydrochloride is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.

(S)-Azelastine hydrochloride is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.

Antazoline phosphate is an antihistamine with anticholinergic properties used to relieve nasal congestion and the symptoms of allergic conjunctivitis. Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles.

S-acetyl-PEG3-alcohol is a PEG Linker.

Lipoamido-PEG2-alcohol is a PEG Linker.

Tetrazine-PEG5-NHS ester is a PEG derivative containing a tetrazine group and an NHS ester. The hydrophilic PEG spacer increases water-solubility. It is one of the most reactive tetrazines commercially available. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics compared to methyl substituted tetrazines.

Methyltetrazine-NHS ester is an NHS actived building block containing a methyltetrazine group. It can react with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. Thus, this reagent can be used for modification of amine-containing molecule in organic media and the low mass weight will add minimal spacer to modified molecules.

Tetrazine-NHS ester is an NHS activated tetrazine derivative. The chemical stability of tetrazines is lower than methyltetrazines, but it is in acceptable range and thus can be applied for many applications. This reagent was found the fastest kinetics for bioorthogonal reaction with trans-cyclooctene (TCO) as the dienophile.

TCO-amine hydrochloride is a simple building block containing a TCO moiety and a free amine. This reagent can be used to derivatize carboxyl groups or activated esters (e.g. NHS esters) with the TCO moiety through a stable amide bond in the presence of of activators (e.g. EDC, or DCC). The low mass weight will add minimal spacer to modified molecules.

TCO-PEG4-NHS ester is a PEG derivative containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins, and other primary amine-containing macromolecules with TCO moiety.

Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG derivative containing one azide group and one D-glucose group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.

Azido-PEG4-alpha-D- mannose is a PEG Linker.