Novel potent and selective dual inhibitor of MDM2 (Ki = 0.9 nM) and MDMX (Ki = 7 nM)

Novel Potent Dual Inhibitor of MDM2 and MDMX (Ki =1 nM)

Natural potent apoptosis inducer in U937 cells, inducing caspase-3 processing, PARP, and DNA fragmentation

Novel antitimor agent, exhibiting superior anti-proliferative activity, excellent chemo-sensitizing activity against pancreatic cancer in vitro and in combination with Gemcitabine

Novel potent inhibitor of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1)

Novel non-toxic contrast agent for micro-CT imaging

Novel inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets

Novel selective A2BR antagonist

Potent JAK2 inhibitor

Selective ß1 receptor antagonist

Novel ROS generator, permeating mycobacteria to reliably enhance endogenous ROS including superoxide radical

Potent cytotoxic agent for both prostate cancer and melanoma

Hydrogen sulfide-releasing cyclooxygenase inhibitor

Novel degrader of MTH1 fusion proteins for use within the aTAG system

Novel inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies

Novel selective nociceptin receptor (NOP) agonist

Nucleosidic antibiotic

Novel dual μ-opioid and nociceptin receptor partial agonist (K i = 16.49 and 3.67 nM, respectively)

High affinity, selective alpha3beta4 nAChR ligand

Novel potent and selective partial agonist of human and rat α3β4 nicotinic cholinergic receptors

Novel NOP receptor-mu opioid receptor ligand

The First Small-molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa and Nociceptin Opioid Receptors.

Novel inhibitor of αSyn fibrillization, blocking fibril growth and suppressing A53T αSyn neurotoxicity

Natural endogenous inhibitor of nitric oxide synthases (NOS), also inhibiting arginine transport and increasing oxygen free radicals, mitochondrial dysfunction and transforming growth factor beta (TGFβ) expression, exhibiting a strong association with car

Inhibitor of HIV-reverse transcriptase activity

Novel AKAP1/PKA modulator, inducing UCP1 expression and thermogenesis

Novel anti-Alzheimer’s agent, inhibiting amyloid β aggregation, β-secretase, and tau aggregation

Novel near-infrared (NIR) probe for imaging β-amyloid (Aβ) plaques or Tau tangles

Novel potent anticancer agent, inhibiting the growth of CRC bulk and sensitized FOLFOX-resistant cells

Natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced x