Novel potent, selective, and orally bioavailable PI3Kdelta inhibitor

Potent GlyT-2 antagonist

Prodrug of ALX5407, a selective non-transportable inhibitor of the glycine transporter GlyT1

Novel lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2) antagonist

Peripherally acting µ-opioid antagonist

Novel selective dual inhibitor of Cdk1/cyclin B and GSK-3β

Specific inhibitor of aldose reductase

Prodrug of Vitamin E, modulating atherosclerotic and inflammatory events more efficiently than the unphosphorylated alpha-tocopherol

Novel modulator of collagen synthesis and matrix metalloproteinases (MMPs) expression levels, boosting collagen synthesis and reducing MMPs expression levels in human fibroblasts without cytotoxicity

Neurotransmitter; stimulating nicotinic receptors

One of the most effective antioxidants, being involved in the cellular antioxidant system

Novel potent inhibitor of the SARS-CoV-2 Mpro, revealing a pronounced lung tropism and suitability for administration by the inhalative route

Psychedelic, an analog of mescaline

Novel inhibitor of JAK2 and STAT5 phosphorylation in response to interleukin-3 without altering STAT5 mobility in SDS-PAGE

Novel JAK2/STAT5 inhibitor

Highly potent, orally effective, and metabolically stable allosteric 5-LOX Inhibitor

Novel potent type I positive allosteric modulator (PAM) of human α7 nAChR

Antioxidant, attenuating collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways

Natural chemical suppressor of mlo-mediated resistance in monocotyledonous barley (Hordeum vulgare) and dicotyledonous Arabidopsis thaliana

Novel allosteric modulator to control endogenous G protein-coupled receptors with light

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

Clickable PPARγ inhibitor

Potent and selective L1196M ALK and ROS1 dual inhibitor

Prodrug of the anthracycline antibiotic doxorubicin, binding selectively to the cysteine-34 position of albumin via its maleimide moiety, inhibiting DNA synthesis, and inducing apoptosis

Novel ALDH inhibitor, inhibiting ALDH3A1 activity in SCC4 HNSCC xenografts

Potent and specific covalent inhibitor of aldehyde dehydrogenases

Novel activator of ALDH3A1

Neuromuscular blocking (NMB) agent

Novel nucleoside phytotoxin