S1R agonist 2 (Compound 8b) is a selective S1R agonist.

(-)-GSK598809 is an isomer of GSK598809. GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans.

Prulifloxacin, also known as NM-441, is an inhibitor of bacterial DNA gyrase used to treat urinary tract infections. Prulifloxacin is an oral fluoroquinolone with a broad in vitro activity spectrum against Gram positive and negative bacteria and among fluoroquinolones has the lowest power of inducing resistance. In vitro and in vivo studies have shown its clinical efficacy and pathogen eradication.

L-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive α-amino, α-carboxyl, and phenolic hydroxyl group. L-tyrosine modulates biofilm formation of Bacillus cereus ATCC 14579. L-Tyrosine Limits Mycobacterial Survival in Tuberculous Granuloma.

SARS-CoV-2-IN-39 (compound 21) is a SARS-CoV-2 inhibitor with an EC50 of 1 μM.

Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb).

Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor.

DC-Y13-27, a derivative of DC-Y13, is a YTHDF2 inhibitor (KD: 37.9 μM).

sEH inhibitor-14 (compound 33) is a benzoxazolone-5-urea analogue.

STAT3-IN-15 is a potent and orally active STAT3 inhibitor.

FC-116 is a Tubulin inhibitor that effectively inhibits tumor growth in mice.

URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor.

Vestitone reductase catalyzes a stereospecific NADPH-dependent reduction of (3R)-vestitone in the bio sysnthesis of antimicrobial isoflavonoid phytoalexin medicarpin.

HDAC-IN-58 is a HDAC inhibitor.

Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44.

HA5 inhibits Streptococcus mutans biofilm.

BCAT-IN-4 (Compound 1) is a BCAT inhibitor.

Orziloben is a medium chain fatty acid (MCFA) analogue.

BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK).

Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor

Pimicotinib, also known as ABSK021, is a tyrosine kinase inhibitor and antineoplastic. It is a small molecule CSF-1R inhibitor that is orally available. Pimicotinib has antitumor activity and a solid white to off-white appearance. Its formula is C22H24N6O3 and its CAS number is 2253123-16-7.

Rezatapopt, also known as PC14586, is p53 Y220C reactivator that binds selectively to p53 Y220C mutant protein and restores the p53 wildtype conformation and transcriptional activity, resulting in potent preclinical antitumor activity. PC14586 was structurally designed to bind tightly to a crevice within the mutant protein (KD~2.5 nM). PC14586 was shown to stabilize the Y220C mutant in the wild type conformation, resulting in reactivation of p53 transcriptional activity and subsequent expression of its target proteins (e.g. p21, MDM2, Bax, PUMA). The reactivation of p53 function is highly selective to Y220C mutant cells and results in arrest of the cell cycle in vitro (IC50 ~0.230-1.8 μM). In nude mice bearing Y220C mutant NUGC3 gastric cancer xenograft tumors, oral administration of PC14586 results in a dose responsive anti-tumor effect. In human xenografts, PC14586 was shown to convert Y220C mutant to the wildtype conformation, resulting in activation of p53 transcription.

MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM.

GPAT-IN-1 is a glycerol-3-phosphate acyltransferase (GPAT) inhibitor

Carfecillin Sodium, also known as Carbenicillin Phenyl Sodium and BRL-3475, is the phenyl ester of Carbenicillin that, upon oral administration, is broken down in the intestinal mucosa to the active antibacterial. It is used for urinary tract infections.

Bifemelane, also known as MCI-2016, is Antidepressant MAO inhibitor used to treat cerebral infarction and Alzheimer's disease. At concentrations of 10 - 30 microM, Bifemelane induced a slow onset and small increase in the [Ca2+]i, while at higher concentrations (100 - 300 microM), it induced a rapid transient increase in the [Ca2+]i during administration and a second large increase was seen during drug washout.

WAY-615145 is a glucokinase activator.

RIG012 is a potent RIG-I inhibitor. It inhibits IFN-β and ISG hRsad2 expression.

CZL55 is a caspase-1 inhibitor. CZL55 can be used for the research of febrile seizures (FS)

Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor.