7-Epipaclitaxel|cas 105454-04-4|DC Chemicals

Cas No.:	105454-04-4
Chemical Name:	7-Epi-Taxol
Synonyms:	7-Epitaxol;7-Epi Paclitaxel;7-Epipaclitaxel, froM Taxus chinensis;EPITAXOL, 7-(P);EPI-TAXOL, 7-(P);7-epi-Taxol;baccatin III N-benzyl-b-phenylisoserine ester;Epitaxol;7-Epipaclitaxel;7-epi-Paclitaxel;AK105059;AOB5624;RCINICONZNJXQF-LYTKHFMESA-N;1246AA;ST24045648
SMILES:	O1C([H])([H])[C@@]2([C@@]1([H])C([H])([H])[C@]([H])([C@@]1(C([H])([H])[H])C([C@@]([H])(C3=C(C([H])([H])[H])[C@]([H])(C([H])([H])[C@](C3(C([H])([H])[H])C([H])([H])[H])([C@]([H])([C@]21[H])OC(C1C([H])=C([H])C([H])=C([H])C=1[H])=O)O[H])OC([C@@]([H])([C@]([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C(C1C([H])=C([H])C([H])=C([H])C=1[H])=O)O[H])=O)OC(C([H])([H])[H])=O)=O)O[H])OC(C([H])([H])[H])=O
Formula:	C₄₇H₅₁NO₁₄
M.Wt:	853.9062
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
Target:	Microtubule/Tubulin[2]
In Vitro:	7-epi-Taxol (7-Epitaxol) is a metabolite of taxol[1]. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization[2].
References:	[1]. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(6):495-502. [2]. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.

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