1-Azakenpaullone|cas 676596-65-9|DC Chemicals

Cas No.:	676596-65-9
Chemical Name:	1-AZAKENPAULLONE
Synonyms:	1-AZAKENPAULLONE;1-Azakenpaullone (1-Akp);1-Azakenpaullone;9-Bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;azakenpaullone;HMS3229B07;Kinome_3492;9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one
SMILES:	CC1C=CC2=C(C3CC(=O)NC4=CC=CN=C4C=3N2)C=1
Formula:	C₁₆H₁₃N₃O
M.Wt:	263.293923139572
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].
Target:	GSK-3β:18 nM (IC50) CDK1/cyclin B:2 μM (IC50) CDK5/p25:4.2 μM (IC50)
References:	[1]. Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6

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