2-Di-1-ASP |cas 2156-29-8| DC Chemicals

Cas No.:	2156-29-8
Chemical Name:	Pyridinium,2-[2-[4-(dimethylamino)phenyl]ethenyl]-1-methyl-, iodide (1:1)
Synonyms:	Pyridinium,2-[2-[4-(dimethylamino)phenyl]ethenyl]-1-methyl-, iodide (1:1);2-(4-(DIMETHYLAMINO)STYRYL)-N-METHYLPYRIDINIUM IODIDE (2-DI-1-ASP);2-(4-Dimethylaminostyryl)-1-Methylpyridinium Iodide;2-DI-1-ASP;(E)-2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide;1-METHYL-2-P-DIMETHYLAMINO-STYRYL-PYRIDINIUM-IODIDE;2-(4-(dimethylamino)styryl)-1-methylpyridinium;2-(4-(Dimethylamino)styryl)-N-methylpyridinium;2-{2-[4-(dimethylamino)phenyl]ethenyl}-1-methylpyridinium iodide;2-<4-(dimethylamino)styryl>-1-ethylpyridinium iodide;2m2Pm;D-308;o-DPD;2-Di-1-ASP
SMILES:	[I-].CN(C1C=CC(/C=C\C2=CC=CC=[N+]2C)=CC=1)C
Formula:	C₁₆H₁₉In₂
M.Wt:	366.239936113358
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].
In Vitro:	2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms (c-kit2, c-kit87up, c-myc)[1].
References:	[1]. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889.

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