7ACC2|cas 1472624-85-3|DC Chemicals

Cas No.:	1472624-85-3
Chemical Name:	7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid
Synonyms:	7ACC-2;7ACC2;compound 19 [PMID: 24095010];7-ACC2;7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid;7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid;7ACC 2;GTPL8818;XTKDQPFUOFAMRL-UHFFFAOYSA-N;BCP11646;BDBM50442711;s6732;AK547419;Q27076338;2-Oxo-7-(methylbenzylamino)-2H-1-benzopyran-3-carboxylic acid;7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
SMILES:	O1C(C(C(=O)O[H])=C([H])C2C([H])=C([H])C(=C([H])C1=2)N(C([H])([H])[H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Formula:	C₁₈H₁₅NO₄
M.Wt:	309.316
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

Cat. No.	Product name	Field of application
DC72788	AZD0095	AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib.
DC11218	BAY-8002	BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM).
DC9263	AZD-3965	AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.
DC7876	7ACC2	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.