Fostemsavir Tris (BMS-663068 (Tris))|CAS 864953-39-9

Cas No.:	864953-39-9
Chemical Name:	BMS-663068 (Tris)
Synonyms:	BMS-663068 (Tris);FOSTEMSAVIR TROMETHAMINE;Fostemsavir Tris
SMILES:	O=C(C(=O)C1C2C(=CN=C(N3C=NC(C)=N3)C=2N(COP(=O)(O)O)C=1)OC)N1CCN(C(=O)C2C=CC=CC=2)CC1.OCC(CO)(N)CO
Formula:	C₂₉H₃₇N₈O₁₁P
M.Wt:	704.624847173691
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

Description:	Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
Target:	HIV-1[1]
In Vivo:	Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].
References:	[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

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Fostemsavir Tris (BMS-663068 Tris)