ALC-0159|CAS 1849616-42-7|DC Chemicals

Cas No.:	1849616-42-7
Chemical Name:	Poly(oxy-1,2-ethanediyl), α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-
Synonyms:	ALC-0159;ALC 0159;ALC0159
SMILES:	O=C(N(CCCCCCCCCCCCCCC)CCCCCCCCCCCCCC)COCCOC
Formula:	(C₂H₄O)NC₃₁H₆₃NO₂
Purity:	>99%
Sotrage:	-20°C, protect from light
Publication:	Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection"" (PDF). Regulation 174. MHRA. 15 December 2020.

Cat. No.	Product name	Field of application
DC40169	DMG-PEG2000	DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modific
DC65786	DSPE-PEG2000-OH (DSPE-PEG hydroxyl)	DSPE-PEG2000-OH is used for creating micelles that are able to carry drugs with low solubility.
DC52020	ALC-0159	ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid). Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.
DC60869	DSPE-mPEG2000	18:0 mPEG2000 PE (DSPE-mPEG2000) is a PEG-based phospholipid. 18:0 mPEG2000 PE can be used to synthesis liposomes for delivering cancer agents.
DC67347	DMG-PEG 1000 (14:1)	A methoxy-terminated PEG1000 functionalized with 1,2-dimyristoleoyl-sn-glycerol via an ether linkage. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC67161	MPEG-2000-DPPE Na	DPPE-MPEG(2000) is a PEGylated form of 1,2-dipalmitoyl-rac-glycero-3-PE (DPPE). It has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention.
DC67112	DPPE-PEG2000	DPPE-PEG2000 (16:0 PEG2000 PE) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo.
DC67111	18:1 PEG2000 PE	18:1 PEG2000 PE (18:1 PEG-PE) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE can be used for drug delivery.
DC60638	Acid-degradable PEG Lipid (ADP-2k)	Acid-degradable PEG Lipid (ADP) composed of polyethylene glycol lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo.
DC58047	DSPE-mPEG2000((sodium salt))	mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.