AT-007|AT007|CAS 2170729-29-8|DC Chemicals

Cas No.:	2170729-29-8
Chemical Name:	2-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid
Synonyms:	AT-007; AT 007; AT007
SMILES:	O=C(CC1=NN(C(=O)C2C1=CSC=2)CC1SC2C(=CC(=CC=2)C(F)(F)F)N=1)O
Formula:	C₁₇H₁₀F₃N₃O₃S₂
M.Wt:	425.40
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. [2]. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.

Description:	AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM[1][2].
Target:	IC50: 100 pM (Aldose Reductase)[2]
References:	[1]. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. [2]. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.

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