Acacetin|cas 480-44-4|DC Chemicals

Cas No.:	480-44-4
Chemical Name:	Acacetin
Synonyms:	Acacetin;5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-on;5,7-dihydroxy-4’-methoxy-flavon;5,7-dioxy-4’-methoxyflavone;acacetine;apisenin4’-methylether;buddleoflavonol;5,7-DIHYDROXY-4'-METHOXYFLAVONE;5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one;5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one;ACACETIN(METHYL-4'-APIGENIN)(AS) PrintBack;ACACETIN(METHYL-4'-APIGENIN)(RG);ACACETIN(METHYL-4'-APIGENIN)(RG) PrintBack;4′-Methylapigenin;5,7-Dihydroxy-4′-methoxyflavone;Apigenin 4′-methyl ether;Linarigenin;Apigenin 4'-Methyl Ether;5,7-dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone;4'-Methoxyapigenin;Linarisenin;Akatsetin;5,7-Dioxy-4'-methoxyflavone;Apisenin 4'-methyl ether;Apigenin 4'-dimethyl ether;Flavone, 5,7-dihydroxy-4'-methoxy-;4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-;4'-Methoxy-5,7-dihydroxyflavone;NSC76061
SMILES:	O1C(=C([H])C(C2=C(C([H])=C(C([H])=C12)O[H])O[H])=O)C1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])[H]
Formula:	C₁₆H₁₂O₅
M.Wt:	284.2635
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration

References:

[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.

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