BAMP-TK-12|ROS‐degradable lipid

Cas No.:
Chemical Name:	BAMP-TK-12
Synonyms:	BAMP TK 12， BAMP-TK-12
SMILES:	CCCCCCCCCCCCOCCSC(C)(C)SCCOC(=O)CCNCCCN1CCN(CCCN(CCC(=O)OCCSC(C)(C)SCCOCCCCCCCCCCCC)CCC(=O)OCCSC(C)(C)SCCOCCCCCCCCCCCC)CC1
Formula:	C₇₆H₁₅₀O₉N₄S₆
M.Wt:	1456.41
Purity:	>98%
Sotrage:	1 years -20°C
Publication:	Weiqi Cai, Tianli Luo, Xianghan Chen, Lanqun Mao, and Ming Wang. “A Combinatorial Library of Biodegradable Lipid Nanoparticles Preferentially Deliver mRNA into Tumor Cells to Block Mutant RAS Signaling.” Advanced Functional Materials 2022, 32, 2204947.

Cat. No.	Product name	Field of application
DC82115	BAMP-TK-12	BAmP-TK-12 is a ROS-responsive ionizable lipid designed for tumor-cell mRNA delivery. It features a bis(aminopropyl)piperazine-derived ionizable headgroup and four C12 tails connected through cleavable thioketal linkers. In the reported study, BAmP-TK-12 achieved RFP expression in up to 95% of HeLa cells, comparable to Lipofectamine 3000, with lower cytotoxicity under the tested conditions. ROS-triggered linker cleavage supported intracellular mRNA release in high-ROS tumor cells. When formulated with DUF5 mRNA, the LNP suppressed tumor growth in HCT-116 and A549 xenograft models, supporting its use as a promising preclinical research lipid for stimulus-responsive mRNA delivery.