BAY11-7082|cas 19542-67-7|DC Chemicals

Cas No.:	19542-67-7
Chemical Name:	(E)-3-Tosylacrylonitrile
Synonyms:	(E)-3-Tosylacrylonitrile;BAY 11-7082;(E)?-?3-?(p-?Toluenesulfonyl)?acrylonitrile;(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile;(E)-3-(P-TOLUENESULFONYL)ACRYLONITRILE;Bay 11-7082 (Bay 11-7821);BAY 11-7821;BAY-11-7082;(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile;BAY 117821;BAY11-7082,BAY 117821;(E)-3-(p-tolylsulfonyl)prop-2-enenitrile;(2E)-3-[(4-METHYLPHENYL)SULFONYL]-2-PROPENENITRILE;BAY117082;4Y5G2A4F6O;3-(4-methylphenylsulfonyl)-2-propenenitrile;3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile;(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile;(2E)-3-[(4
SMILES:	S(/C(/[H])=C(\[H])/C#N)(C1C([H])=C([H])C(C([H])([H])[H])=C([H])C=1[H])(=O)=O
Formula:	C₁₀H₉NO₂S
M.Wt:	207.249
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BAY 11-7082 is a NF-κB inhibitor which decreases NF-κB by inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50s of 0.19 μM and 0.96 μM, respectively.

In Vitro:

Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line[1]. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A[2]. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ[3]. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules[4].

Cat. No.	Product name	Field of application
DC42357	NF-κΒ activator 1	NF-κΒ activator 1 is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 mRNA expression.
DC10636	SC75741	SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.
DC7741	JSH-23	JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.
DC10768	IT 901	IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro.
DC8827	Didox	Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers.
DC8038	Bay 11-7085	BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with an IC50 value of 10 μM.
DC7869	BAY11-7082	BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Also inhibiting components of the ubiquitin system.