BMS-986251|CAS 2460133-35-9|DC Chemicals

Cas No.:	2460133-35-9
Chemical Name:	BMS-986251
Synonyms:	BMS-986251
SMILES:	[C@H]1([C@H](C(=O)N2[C@@]3(CCC4=CC(C(C(F)(F)F)(F)C(F)(F)F)=CC=C4[C@]3(S(=O)(=O)C3C=CC(F)=CC=3)CC2)[H])CC[C@@H](C(=O)O[H])C1)C
Formula:	C₃₀NO₅F₈SH₂₉
M.Wt:	667.6072
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

Cat. No.	Product name	Field of application
DC70267	BMS-986313	BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model).
DC40965	BMS-986251	BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis).
DC28745	FM26	FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.
DC9713	GSK2981278	GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).