CB 5083,CB5083|cas 1542705-92-9|p97 inhibitor

Cas No.:	1542705-92-9
Chemical Name:	CB-5083
Synonyms:	CB-5083;CB5083;591IV6UL6J;AK173785;1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide;1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide;BCP23807;CB 5083;S8101;J3.551.815K;1-(7,8-Dihydro-4-((phenylmethyl)amino)-5H-pyrano(;1542705-92-9;CCG-268805;BDBM50500325;p97 Inhibitor CB-5083;HY-12861;UNII-591IV6UL6J;BRD-K49048664-001-02-0;CB-5083; CB 5083;EX-A773;MFCD28963914;BRD-K49048664-001-01-2;(1-(4-(benzylamino)-5H,7H,8H-pyrano(4,3-d)pyrimidin-2-yl))-2-methyl-1H-indole-4-carboxamide;DTXSID801022542;BC177445;1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide;CHEMBL3747513;CB 5083 [WHO-DD];CB-5083?;AC-29018;NSC786100;CS-5405;NSC-786100;JDP;AS-55872;AKOS025396184;NCGC00481317-01;SCHEMBL15421452;1-[4-(BENZYLAMINO)-5H,7H,8H-PYRANO[4,3-D]PYRIMIDIN-2-YL]-2-METHYLINDOLE-4-CARBOXAMIDE;1-(7,8-Dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide;1H-Indole-4-carboxamide, 1-(7,8-dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl-;NCGC00481317-03;DA-71987;HMS3873E13
SMILES:	O1C([H])([H])C([H])([H])C2=C(C(N([H])C([H])([H])C3C([H])=C([H])C([H])=C([H])C=3[H])=NC(=N2)N2C(C([H])([H])[H])=C([H])C3=C(C(N([H])[H])=O)C([H])=C([H])C([H])=C23)C1([H])[H]
Formula:	C₂₄H₂₃N₅O₂
M.Wt:	413.4717
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.

Cat. No.	Product name	Field of application
DC8840	CB-5083	CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models .