CGP4540(Amoscanate)|CAS: 100990-46-3|DC Chemicals

Cas No.:	100990-46-3
Chemical Name:	Amoscanate
Synonyms:	CGP4540 (Amoscanate);(4-Isothiocyanato-phenyl)-(4-nitro-phenyl)-amine;Amoscanate;Nithiocyamine;Amoscanatum;Amoscanato;Ciba 9333 GO;4-(4-Nitroanilino)phenylisothiocyanat;4-Isothiocyanato-4'-nitrodiphenylamine;p-(p-Nitroanilino)phenyl isothiocyanate;4-isothiocyanato-N-(4-nitrophenyl)aniline;CGP 4540;4-Isothiocyanato-N-(4-nitrophenyl)benzenamine;C 9333 GO;GO 9333;CGP4540;X0MK46CVRB;ISOTHIOCYANIC ACID, p-(p-NITROANILINO)PHENYL ESTER;Benzenamine, 4-isothiocyanato-N-(4-nitrophenyl)- (9CI);(4-Isothiocyanato-ph
SMILES:	S=C=NC1C=CC(=CC=1)NC1C=CC(=CC=1)[N+](=O)[O-]
Formula:	C₁₃H₉N₃O₂S
M.Wt:	271.294461011887
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
In Vivo:	Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1]. Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1]. Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1]. Amoscanate elicits massive ultrastructural damage in ependymal cells[1]. Animal Model: Sprague-Dawley rats[1] Dosage: 500 mg/kg Administration: P.o.; 10 days Result: Destructed ependyma and periventricular brain. Animal Model: Sprague-Dawley rats[1] Dosage: 250 and 500 mg/kg Administration: P.o.; 28 days Result: Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum. Animal Model: Sprague-Dawley rats[1] Dosage: 25~500 mg/kg Administration: P.o.; 20 days Result: Elicited progressive necrosis of ependymal.
References:	[1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.

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