Carmustine|cas 154-93-8|DC Chemicals

Cas No.:	154-93-8
SMILES:	ClCCN(N=O)C(NCCCl)=O
Formula:	C₅H₉Cl₂N₃O₂
M.Wt:	214.05
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
In Vivo:	Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2].
In Vitro:	Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1].

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