Corylifolinin|cas 20784-50-3|DC Chemicals

Cas No.:	20784-50-3
Chemical Name:	Isobavachalcone
Synonyms:	2-Propen-1-one,1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-;Isobavachalcone;(E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one;CORYLIFOLIN CORYLIFOLININ;2',4',4-trihydroxy-3'-prenylchalcone;4,2',4'-trihydroxy-3'-prenylchalcone;4-Hydroxyisocordoim;4-Hydroxyisocordoin;Corylifolinin;Isobacachalcone;(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;2′,4,4′-Trihydroxy-3′-(3-methyl-2-butenyl)-chalcone;(E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone;(E)-1-(2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
SMILES:	O([H])C1=C(C(/C(/[H])=C(\[H])/C2C([H])=C([H])C(=C([H])C=2[H])O[H])=O)C([H])=C([H])C(=C1C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])O[H]
Formula:	C₂₀H₂₀O₄
M.Wt:	324.3704
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.IC50 value:Target: Isobavachalcone inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.

References:

[1]. Jing Hui; Zhou Xinglu; Dong Xiaowu; Cao Ji; Zhu Hong; Lou Jianshu; Hu Yongzhou; He Qiaojun; Yang Bo Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.Cancer letters (2010), 294(2):167-177 [2]. Nishimura R et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull. 2007 Oct;30(10):1878-83. [3]. Zhao S, et al. Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.Int J Mol Med. 2012 Jul 16. [4]. Kuete V, Sandjo LP.Isobavachalcone: an overview.Chin J Integr Med. 2012 Jul;18(7):543-7. Epub 2012 Jul 7. [5]. Zhang Y, Chen Z.Separation of isomeric bavachin and isobavachalcone in the fructus Psoraleae by capillary electrophoresis-mass spectrometry.J Sep Sci. 2012 Jul;35(13):1644-50.

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Corylifolinin(Isobavachalcone)