Curcurbitacin IIa|cas 58546-34-2|DC Chemicals

Cas No.:	58546-34-2
Chemical Name:	Cucurbitacin IIa
Synonyms:	Cucurbitacin A;CUCURBITACIN IIA;23,24-Dihydrocucurbitacin F-25-O-acetate;25-Acetoxy-23,24-dihydrocucurbitacin F;25-O-Acetyl-23,24-dihydrocucurbitacin F;Dihydrocucurbitacin F 25-O-acetate;Dihydrocucurbitacin Q1;[(6R)-6-hydroxy-2-methyl-5-oxo-6-[(2S,3S,8S,9R,10R,13R,14S,16R,17R)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]heptan-2-yl] aceta;Hemslecin A;Cucurbitacin IIa;Curcurbitacin Q1;X1160;Curcurbitacin IIa;C32H50O8
SMILES:	O([H])[C@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])=C4C(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])([C@]([H])(C([H])([H])[C@@]4([H])[C@]3(C([H])([H])[H])C(C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])[C@@](C(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])OC(C([H])([H])[H])=O)=O)(C([H])([H])[H])O[H])=O)O[H])O[H]
Formula:	C₃₂H₅₀O₈
M.Wt:	562.7346
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells[1].
References:	[1]. Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9.

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