Balamapimod|MKI-833;MKI833

Cas No.:	863029-99-6
Chemical Name:	4-[[3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl]amino]-6-methoxy-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-3-quinolinecarbonitrile
Synonyms:	MKI-833;MKI833
SMILES:	N1C2C(=CC(OC)=C(N3CCC(N4CCCC4)CC3)C=2)C(NC2=CC=C(SC3N(C)C=CN=3)C(Cl)=C2)=C(C#N)C=1
Formula:	C₃₀H₃₂ClN₇Os
M.Wt:	574.144
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential.

Cat. No.	Product name	Field of application
DC42418	ML786 dihydrochloride	ML786 dihydrochloride potent and orally bioavailable Raf, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.
DC8777	CEP-32496 hydrochloride	CEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
DC10994	Balamapimod	Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential..