Baloxavir acid|S-033447|CAS 1985605-59-1|DC Chemicals

Cas No.:	1985605-59-1
Chemical Name:	(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione
Synonyms:	Baloxavir; Baloxavir acid; BXA
SMILES:	N12C=CC(=O)C(O)=C1C(=O)N1CCOC[C@]1([H])N2[C@@H]1C2=CC=C(F)C(F)=C2CSC2=CC=CC=C21
Formula:	C₂₄H₁₉F₂N₃O₄S
M.Wt:	483.49
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Baloxavir is an anti-influenza agent extracted from patent WO 2017104691 A1.
Target:	Influenza virus[1]
References:	[1]. Shishido Takao, et al. Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug. WO 2017104691 A1.

Cat. No.	Product name	Field of application
DC72995	ING-1466	ING-1466 is an orally active entry inhibitor of influenza A viruses (IAVs) with EC50 of 0.18 uM against IAV H1N1 (PR8-NS1-Gluc), binds to hemagglutinin (HA) and blocks HA-mediated viral infection.
DC11030	S119-8	S119-8 is a novel broad spectrum inhibitor of influenza virus replication (IC50=1.43 nM) by targeting the viral Nucleoprotein (NP), with no detectable cytotoxicity (CC50>50 uM).
DC9486	Nucleozin	Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.
DC1108	Laninamivir (CS-8958)	Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.
DC11057	Baloxavir acid	Baloxavir acid (S-033447) is an anti-influenza compound that potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses.