ADX-102|Reproxalap;NS-2|CAS 916056-79-6|DC Chemicals

Cas No.:	916056-79-6
Chemical Name:	2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol
Synonyms:	Reproxalap;NS-2;ADX102;ADX 102
SMILES:	CC(C1C(N)=CC2C(N=1)=CC=C(Cl)C=2)(O)C
Formula:	C₁₂H₁₃ClN₂O
M.Wt:	236.699
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1: Bansal N, Janveja C, Tewari R, Soni R, Soni SK. Highly thermostable and pH-stable cellulases from Aspergillus niger NS-2: properties and application for cellulose hydrolysis. Appl Biochem Biotechnol. 2014 Jan;172(1):141-56. doi: 10.1007/s12010-013-0511-9. Epub 2013 Sep 20. PubMed PMID: 24052336.

Description:	Reproxalap (ADX-102) is a reactive aldehyde species (RASP) sequestering agent for the treatment of dry eye. Reproxalap (ADX-102) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal[1][2].
References:	[1]. Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain. [2]. Reproxalap Phase 2b Dry Eye Disease Results.

Cat. No.	Product name	Field of application
DC11097	ADX-102 (Reproxalap;NS-2)	ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease.

ADX-102 (Reproxalap;NS-2)