ABX-1431 hydrochloride|cas 2043074-64-0|DC Chemicals

Cas No.:	2043074-64-0
Chemical Name:	ABX-1431 hydrochloride
Synonyms:	1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate hydrochloride;ABX-1431 hydrochloride
SMILES:	Cl[H].FC(C1C([H])=C([H])C(=C(C=1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])(C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H])(F)F
Formula:	C₂₀H₂₃ClF₉N₃O₂
M.Wt:	543.8542
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical

References:

1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951. View Related Products by Target Monoacylglycerol Lipase (MAGL) Pain

Cat. No.	Product name	Field of application
DC11183	ABX-1431 hydrochloride	ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).
DC11155	ABX-1431	ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).