INU-101 |CAS 1513828-41-5|DC Chemicals

Cas No.:	1513828-41-5
Chemical Name:	(1S,3R,4S,5S,7S)-4-(2-((2-fluorophenyl)sulfonamido)-2-methylpropanamido)adamantane-1-carboxamide
Synonyms:	INU101;INU 101
SMILES:	[C@](C(N)=O)12C[C@]([H])3C[C@]([H])(C[C@]([H])([C@@H]3NC(=O)C(NS(C3=CC=CC=C3F)(=O)=O)(C)C)C1)C2
Formula:	C₂₁H₂₈FN₃O₄S
M.Wt:	437.53
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively; displays good selectivity for human 11β-HSD1 over 11β-HSD2 (IC50>10 uM); significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes (IC50=9.1 nM), enhances insulin sensitivity and lowers the fasting blood glucose level in KKAy mice, ob/ob mice and ZDF rats after oral administration, decreases the body weight and ameliorates an improved lipid profile in the diabetic mouse model.

Cat. No.	Product name	Field of application
DC8278	BVT-14225	BVT 14225 is a new selective 11b-HSD1 inhibitor, it belongs to a class of arylsulfonamidothiazoles with in vitro and in vivo antidiabetic effects
DC11205	INU-101	INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively.
DC11206	HSD-016	HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
DC11019	ASP3662	ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM.