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| Cas No.: | 1219624-62-0 |
| Chemical Name: | 1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one |
| Synonyms: | A 1048400 |
| SMILES: | N(CC(N1CCN(C(C2=CC=CC=C2)C2=CC=CC=C2)CC1)=O)1CCCC(C2=CC=CC=C2)(C2=CC=CC=C2)C1=O |
| Formula: | C36H37N3O2 |
| M.Wt: | 543.711 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively; shows no significant activity against L-type Ca2+ channels (IC50=28 uM); reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function; blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo. |