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| Cas No.: | 1202269-24-6 |
| Chemical Name: | 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-yl)carbonylpiperidin-3-yl]-1H-benzimidazole-2-carboxamide hydrochloride |
| Synonyms: | TAK-272;TAK 272 hydrochloride;TAK272 |
| SMILES: | C(C(N(CC(C)C)[C@@H]1C[C@H](C(N2CCOCC2)=O)CNC1)=O)1N(CCCCOC)C2=CC=CC=C2N=1.[H]Cl |
| Formula: | C27H42ClN5O4 |
| M.Wt: | 536.114 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo. |