WIN-18446|WIN18446;WIN 18446

Cas No.:	1477-57-2
Chemical Name:	N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Synonyms:	WIN18446;WIN 18446
SMILES:	O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
Formula:	C₁₂H₂₀Cl₄N₂O₂
M.Wt:	366.11
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM; potently inhibits spermatogenesis and causes infertility in vivo by inhibiting retinoic acid synthesis.

Cat. No.	Product name	Field of application
DC47762	MeDTC	MeDTC (S-Methyl-N,N-diethylthiocarbamate Sulfone), a Disulfiram metabolite, is a potent, irreversible aldehyde dehydrogenase (ALDH) inhibitor.
DC41113	NCT-501 hydrochloride	NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
DC40990	BODIPY aminoacetaldehyde	BODIPY aminoacetaldehyde (BAAA) is a fluorescent substrate for both murine and human aldehyde dehydrogenase (ALDH). BODIPY aminoacetaldehyde consists of an aminoacetaldehyde moiety bonded to the BODIPY fluorochrome and can be used to label stem cells.
DC29232	NCT-507 (NCT507)	NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases; also exhibits IC50 of 53 nM in MIA PaCa-2 Aldefluor cell-based assays; demonstrates target engagement in CETSA asssays, inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.
DC29187	4-Diethylaminobenzaldehyde	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM).
DC8857	NCT-501	NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
DC11025	DKM 3-42	DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity.
DC11024	ALDH3A1 inhibitor EN40	ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM.
DC11624	WIN-18446	A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.