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| Cas No.: | 2092917-19-4 |
| Chemical Name: | 3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile |
| SMILES: | C(#N)C1=CC(F)=CC(OCC2=CC=CC3C2=C(N)N=C(N)N=3)=C1 |
| Formula: | C16H12FN5O |
| M.Wt: | 309.304 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism. |