ABP-A3|ABP A3

Cas No.:
Chemical Name:	((2R,3S,4R,5R)-5-(6-((4-ethynylphenyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate
Synonyms:	ABP A3
SMILES:	S(N)(OC[C@H]1[C@H](O)[C@H](O)[C@@H](N2C3C(N=C2)=C(NC2=CC=C(C#C)C=C2)N=CN=3)O1)(=O)=O
Formula:	C₁₈H₁₈N₆O₆S
M.Wt:	446.438
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes; inhibits conjugation of ubiquitin to intracellular proteins and prevents the formation of cytoprotective aggresomes; induces activation of the unfolded protein response (UPR) and apoptosis, displays IC50 of 2.5 uM in cell viability assays in A549 cells.

Cat. No.	Product name	Field of application
DC28777	Ubiquitination-IN-1	Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors.
DC9430	PYZD-4409	PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).
DC11762	ABP-A3	ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.
DC11766	UbcH5c-IN-6d	A potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
DC11767	IJ-5	A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
DC11763	ABP 1	A nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro.