GRK2-IN-115h hydrochloride|GRK2 inhibitor 115h hydrochloride

Cas No.:	1941168-71-3
Synonyms:	GRK2 inhibitor 115h hydrochloride
Formula:	C₂₄H₂₂ClF₃N₆O
M.Wt:	502.926
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment.

Cat. No.	Product name	Field of application
DC11956	CCG 258748	A potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM.
DC11957	CCG 224061	A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 66 nM.
DC11958	CCG 258001	A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 280 nM.
DC11765	GRK2-IN-115h hydrochloride	A highly potent and selective GRK2 inhibitor with IC50 of 18 nM.