IHR-1|IHR 1;IHR1

Cas No.:	548779-60-8
Chemical Name:	N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)
Synonyms:	IHR 1;IHR1
SMILES:	C(NC(=O)C1=CC(Cl)=CC=C1Cl)1=CC=C(NC(=O)C2=CC(Cl)=CC=C2Cl)C=C1
Formula:	C₂₀H₁₂Cl₄N₂O₂
M.Wt:	454.13
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.

Cat. No.	Product name	Field of application
DC47157	KAAD-Cyclopamine	KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist.
DC40460	IHR-Cy3	IHR-Cy3 is a potent fluorescent Smo antagonist with an IC50?of 100 nM.
DC12288	MRT-83	MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range.
DC11784	IHR-Nac	A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay.
DC11785	IHR-1	A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.