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| Cas No.: | 380572-02-1 |
| Chemical Name: | 5,6-Dihydro-6-[(4-hydroxy-3-methoxyphenyl)methylene]-5-imino-2-(trifluoromethyl)-7H-1,3,4-thiadiazolo[3,2-a]pyrimidin-7-one |
| Synonyms: | SRPIN 803;SRPIN803 |
| SMILES: | C12SC(C(F)(F)F)=NN1C(=N)/C(=C/C1=CC=C(O)C(OC)=C1)/C(=O)N=2 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2; prevents VEGF production more effectively than SRPIN340, topical administration of SRPIN803 suppresses intraocular neovascularization in mouse model. |