PAT-048|PAT 048;PAT048

Cas No.:	1359983-15-5
Chemical Name:	3-((6-chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid
Synonyms:	PAT 048;PAT048
SMILES:	C(O)(=O)C1=CC=CC(SC2C3=C(N(C4=CN(CCC)N=C4)C=2C)C(F)=C(Cl)C=C3)=C1F
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX; exhibits good potency for inhibition of lysoPLD activity with IC50 of 8.9 nM and 22 nM in human blood and mouse plasma, respectively; decreases ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis in bleomycin-challenged mice.

Cat. No.	Product name	Field of application
DC11991	PAT-505	PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
DC11992	PAT-048	PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
DC11993	GWJ-A-23	GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound.
DC11602	BI-2545	BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively.