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| Cas No.: | |
| Chemical Name: | 4-(6-amino-5-(4-cyanophenyl)pyridin-3-yl)-N-isopropylbenzamide |
| Synonyms: | PF 794;PF794 |
| SMILES: | C(NC(C)C)(=O)C1=CC=C(C2=CC(C3=CC=C(C#N)C=C3)=C(N)N=C2)C=C1 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays; displays excellent kinome selectivity with exception of MINK1 and MAP4K4 (>60% inhibition at 1 uM); significantly inhibits TNIK-induced phosphorylation of p120-catenin, reduces pT312-immunoprecipitated p120-catenin in neurons. |