COH000|CAS 1534358-79-6

Cas No.:	1534358-79-6
Synonyms:	COH000，COH-000，COH 000
SMILES:	CC(C=C1)=CC=C1C[C@@H](NC2=CC=CC=C2)[C@]34C(C(OC)=O)=C(C(OC)=O)[C@@H](O4)C=C3
Formula:	C₂₅H₂₅NO₅
M.Wt:	419.47
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:	COH000 is an inhibitor of Ubiquitin-like 1-activating enzyme (SUMO-activating enzyme), with an IC50 of 0.2 μM for SUMOylation in vitro[1].
Target:	IC50: 0.2 μM (SUMO-activating enzyme)[1].
In Vitro:	COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].
References:	[1]. Li YJ, et al. Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6.

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