Pyrrolidinedithiocarbamate ammonium;APDC, PDTC|cas 5108-96-3|DC Chemicals

Cas No.:	5108-96-3
Chemical Name:	Pyrrolidine dithiocarbamic acid
Synonyms:	1-Pyrrolidinecarbodithioic acid, ammoniumsalt;Ammonium pyrrolidinedithiocarbamate~APDC;APDC;APDTC;Pyrrolidinedithiocarbamate;ammonium pyrrolidine-1-carbodithioate;Ammonium tetramethylenedithiocarbamate;PYRROLIDINE-N-DITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;PYRROLIDINEDITHIOCARBAMATE, AMMONIUM DERIVATIVE;PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMONIUM SALT;Ammonium pyrrolidinedithiocarbamate;Ammonium 1-Pyrrolidinecarbodithioate [Reagent for Atomic Absorption Analysis];Ammonium 1-pyrrolidinedithiocarbamate;PDTC (PDC, APDC, Pyrrolidinedithiocarbamate Ammonium);Pyrrolidinedithiocarbamate (ammonium);1-PYRROLIDINECARBODITHIOIC ACID;1-Pyrrolidinecarbodithioic acid ammonium salt,APDC,Ammonium pyrrolidinecarbodithioate;1-Pyrrolidinedithiocarboxylic acid ammonium salt;Ammonium 1-Pyrrolidinecarbodithioate;Ammonium pyrrolidine;Ammonium Pyrrolidine-N-dithiocarbamate;Ammoniumpyrrolidinedithiocarb;APCD;APDC AMMONIUM SALT;APDTC AMMONIUM SALT;PDC;PDTC;Pyrrolindinedithiocarbamate ammonium;1-Pyrrolidinecarbodithioic Acid Ammonium Salt;Pyrrolidine dithiocarbamate;Pyrrolidine-1-carbodithioic acid;Pyrrolidine dithiocarbamic acid;Tetramethylenedithiocarbamic acid;Pyrrolidine-N-carbodithioic acid;Ammonium pyrrolidine dithiocarbamate;1-Pyrrolidinecarbodithioic acid, ammonium salt;C5H9NS2;NSC298194;ammonium tetramethylene dithiocarbamate;NCIOpen2_00
SMILES:	S([H])C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=S
Formula:	C₅H₉NS₂
M.Wt:	147.2617
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor.
In Vivo:	The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2].
In Vitro:	Pretreatment of cells with pyrrolidinedithiocarbamate (3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate inhibits the activation of NF-κB, because pyrrolidinedithiocarbamate suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate decrease IL-8 production by intestinal epithelial cells[1].

Cat. No.	Product name	Field of application
DC82301	IC-8	IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
DC75721	CL2A-SN38 (Govitecan)	CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
DC46471	RP101988	RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.
DC37901	PD-173212	PD-173212 is a small molecule N-type calcium channel blocker.
DC37333	N,N-Diethyl-p-toluamide	N,N-Diethyl-p-toluamide is a mosquito repellent.
DC37321	AI3-15902	AI3-15902 is a biochemical.
DC37283	Methyl phenylcarbamate	Methyl phenylcarbamate is a biochemical.
DC37252	Ampyrone	Ampyrone is a metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.
DC37245	Piperonyl butoxide	Piperonyl butoxide (PBO) is an organic compound used as a component of pesticide formulations. It is a waxy white solid. It is a synergist. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.[1] It is a semisynthetic derivative of safrole.
DC34632	MDL800	MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.